N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; I-beta-1,3-N-acetylglucosaminyltransferase; iGnT; poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betagal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1, B3GNT6)

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^[1]^[2]^[3]^[4]

Function

can initiate synthesis or elongation of linear poly-N-acetyllactosaminoglycans
protein modification; protein glycosylation

Compartment

Golgi membrane; single-pass type 2 membrane protein

Expression

in the adult
- highly expressed in heart, brain, skeletal muscle & kidney
- lower expression in placenta, pancreas, spleen, prostate, testis, ovary, small intestine & colon
- very weak expression in lung, liver, thymus & peripheral blood leukocytes
in fetus
- highly expressed in brain & kidney
- lower expression in lung & liver

More general terms

References

↑ UniProt http://www.uniprot.org/uniprot/O43505.html
↑ GGDB; Note: glycogene database http://riodb.ibase.aist.go.jp/rcmg/ggdb/
↑ SeattleSNPs http://pga.gs.washington.edu/data/b3gnt6/
↑ Functional glycomics gateway - GTase; Note: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_547

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11041
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11041
OMIM: https://mirror.omim.org/entry/605517
UniProt: http://www.uniprot.org/uniprot/O43505.html

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