V-type proton ATPase 116 kD subunit a isoform 1; V-ATPase 116 kD isoform a1; vacuolar proton translocating ATPase 116 kD subunit a isoform 1; clathrin-coated vesicle/synaptic vesicle proton pump 116 kD subunit; vacuolar proton pump subunit 1; vacuolar adenosine triphosphatase subunit Ac116 (ATP6V0A1, ATP6N1, ATP6N1A, VPP1)

Function

• required for assembly & activity of the vacuolar ATPase
• role in differential targeting & regulation of the V-ATPase for a specific organelle (putative)

Structure

belongs to the V-ATPase 116 kD subunit family

Compartment

• cytoplasmic vesicle membrane, multi-pass membrane protein
• melanosome, stage 1-4
• coated vesicle

Alternative splicing

named isoforms=2

More general terms

• protein subunit
• phosphoprotein
• transmembrane 8 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=535
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:535
• OMIM: https://mirror.omim.org/entry/192130
• UniProt: http://www.uniprot.org/uniprot/Q93050.html