gamma-glutamyltransferase 7; GGT 7;gamma-glutamyltransferase-like 3; gamma-glutamyltransferase-like 5; gamma-glutamyltranspeptidase 7; contains: gamma-glutamyltransferase 7 heavy chain; gamma-glutamyltransferase 7 light chain (GGT7, GGTL3, GGTL5)

Function

• glutathione metabolism
• cleaves glutathione conjugates
• Isoform 5 interacts with CT120

Structure

• heterodimer composed of the light & heavy chains, both derived from same precursor
• active site located in the light chain

Compartment

membrane

Alternative splicing

named isoforms=6

Expression

• expressed in brain, heart, kidney, liver, lung, spleen, testis, trachea

More general terms

• gamma-glutamyltransferase (GGT) or gamma-glutamyltranspeptidase
• membrane protein
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2686
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2686
• OMIM: https://mirror.omim.org/entry/612342
• UniProt: http://www.uniprot.org/uniprot/Q9UJ14.html