mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; mannosidase alpha class 1A member 2; Processing alpha-1,2-mannosidase IB; alpha-1,2-mannosidase IB (MAN1A2, MAN1B)

Function

• maturation of Asn-linked oligosaccharides, N-glycosylation
• hydrolysis of the terminal 1,2-linked alpha-D- mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)
• progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

Cofactor: Ca+2

Inhibition:

• inhibited by 1-deoxymannojirimycin & kifunensine

Structure

belongs to the glycosyl hydrolase 47 family

Compartment

• Golgi membrane
• single-pass type 2 membrane protein

Expression

• highest levels of expression in placenta & testis

More general terms

• membrane protein
• hydrolase
• Ca+2 binding protein
• glycoprotein

Additional terms

• Asn glycosylation

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10905
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10905
• OMIM: https://mirror.omim.org/entry/604345
• UniProt: http://www.uniprot.org/uniprot/O60476.html