alpha-1,3/1,6-mannosyltransferase ALG2; asparagine-linked glycosylation protein 2 homolog; GDP-man:man(1)GlcNAc(2)-PP-dol alpha-1,3-mannosyltransferase; GDP-man:man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; GDP-man:man(2)GlcNAc(2)-PP-dol alpha-1,6-mannosyltransferase (ALG2)

Function

• mannosylates man(2)GlcNAc(2)-dolichol diphosphate & man(1)GlcNAc(2)-dolichol diphosphate to form man(3)GlcNAc(2)-dolichol diphosphate
• protein modification; protein glycosylation

Structure

• belongs to the glycosyltransferase group 1 family glycosyltransferase 4 subfamily

Compartment

membrane (potential)

Alternative splicing

named isoforms=2

Pathology

• defects in ALG2 are the cause of congenital disorder of glycosylation type 1I

More general terms

• membrane protein
• glycosyltransferase

Additional terms

• congenital disorder of glycosylation type 1H

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85365
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85365
• OMIM: https://mirror.omim.org/entry/607905
• OMIM: https://mirror.omim.org/entry/607906
• UniProt: http://www.uniprot.org/uniprot/Q9H553.html