serine palmitoyltransferase 2; long chain base biosynthesis protein 2; LCB 2; long chain base biosynthesis protein 2a; LCB2a; serine-palmitoyl-CoA transferase 2; SPT 2 (SPTLC2, KIAA0526, LCB2)

Function

• component of the serine palmitoyltransferase complex
• the heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core
• the composition of the serine palmitoyltransferase complex determines the substrate preference
• the SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate
• the SPTLC1-SPTLC2-SSSPTB complex displays a preference for C18-CoA substrate
• lipid metabolism; sphingolipid metabolism
• heterodimer with SPTLC1

Cofactor:

• pyridoxal phosphate (putative)

Structure

• belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Compartment

• endoplasmic reticulum membrane
• single-pass membrane protein (putative)

Expression

widely expressed

Pathology

• defects in SPTLC2 are the cause of hereditary sensory & autonomic neuropathy type 1C

More general terms

• transferase
• protein subunit
• membrane protein

Component of

• serine palmitoyltransferase (SPT) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9517
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9517
• OMIM: https://mirror.omim.org/entry/605713
• OMIM: https://mirror.omim.org/entry/613640
• UniProt: http://www.uniprot.org/uniprot/O15270.html