protein tyrosine phosphatase type IVA, member 3; protein tyrosine phosphatase 4a3; protein-tyrosine phosphatase of regenerating liver-3; PRL-3; PRL-R (PTP4A3, PRL3)

Function

• stimulates progression from G1 into S phase during mitosi
• enhances cell proliferation, cell motility, invasive activity
• promotes cancer metastasi
• progression of cardiac hypertrophy via inhibiting intracellular Ca+2 mobilization in response to angiotensin-2

Structure

farnesylated

Compartment

plasma membrane & early endosome

Expression

expressed in cardiomyocytes, skeletal muscle, pancreas

Pathology

overexpressed in colon cancer metastasis

More general terms

• protein tyrosine phosphatase type IVA
• membrane protein

Additional terms

• adenocarcinoma of the colon &/or rectum
• metastasis

Database

• OMIM: https://mirror.omim.org/entry/606449
• UniProt: http://www.uniprot.org/uniprot/O75365.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11156