mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; alpha-1,2-mannosidase IA; mannosidase alpha class 1A member 1; man(9)-alpha-mannosidase; man9-mannosidase (MAN1A1)

Function

• role in maturation of Asn-linked oligosaccharides
• progressively trims alpha-1,2-linked mannose residues from man(9)GlcNAc(2) to produce man(5)GlcNAc(2)
• inhibited by both 1-deoxymannojirimycin & kifunensine
• protein modification; protein glycosylation
• hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide man(9)(GlcNAc)(2)

Cofactor: Ca+2

Structure

belongs to the glycosyl hydrolase 47 family

Compartment

Golgi membrane

Laboratory

• higher urinary levels of MAN1A1 portend a lower risk of death or hopsitalization for heart failure in patients with HFpEF

More general terms

• alpha-mannosidase (MANA)
• Ca+2 binding protein
• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P33908.html
• OMIM: https://mirror.omim.org/entry/154580
• OMIM: https://mirror.omim.org/entry/604344
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4121
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4121