L-dopachrome tautomerase; DCT; DT; L-dopachrome delta-isomerase; tyrosinase-related protein 2; TRP-2; TRP2 (DCT, TYRP2)

Function

• role in regulating eumelanin & phaeomelanin levels
• tyrosinase, TYRP1 & TYRP2 may form a multienzyme complex (putative)
• pigment biosynthesis; melanin biosynthesis

L-dopachrome <--> 5,6-dihydroxyindole-2-carboxylate

Cofactor: binds 2 Zn+2 per subunit (putative)

Structure

belongs to the tyrosinase family

Compartment

melanosome membrane

More general terms

• oxidoreductase
• membrane protein
• glycoprotein
• metalloprotein

Additional terms

• D-dopachrome decarboxylase; D-dopachrome tautomerase; phenylpyruvate tautomerase 2 (DDT)
• tyrosinase (monophenol monooxygenase, tumor rejection antigen AB, SK29-AB, LB24-AB, TYR)

Database

• UniProt: http://www.uniprot.org/uniprot/P40126.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1638
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1638
• OMIM: https://mirror.omim.org/entry/191275