sialyltransferase 8D; alpha-2,8-polysialyltransferase; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (SIAT8D, ST8SIAIV, ST8SIA4)

Function

• catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells
• protein modification; protein glycosylation

Structure

belongs to the glycosyltransferase 29 family

Compartment

Golgi membrane

Expression

• expressed in fetal brain, lung & kidney & in adult heart, spleen & thymus > adult brain, placenta, lung, colon & small intestine & peripheral blood leukocytes

More general terms

• sialyltransferase
• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/602547
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7903
• UniProt: http://www.uniprot.org/uniprot/Q92187.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7903