sialyltransferase 8C; Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase; alpha-2,8-sialyltransferase 8C (ST8SIA3)

Function

• may transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked & alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins & glycolipids
• it can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid
• protein modification; protein glycosylation

Structure

belongs to the glycosyltransferase 29 family

Compartment

Golgi membrane

Expression

expressed in fetal & adult brain & fetal liver

More general terms

• sialyltransferase
• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O43173.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5104
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51046