sialyltransferase 8B; sialyltransferase X; alpha-2,8-sialyltransferase (ST8SIAII, SIAT8B, ST8SIA2)

Function

• may transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked & alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins
• may be involved in polysialic acid expression
• protein modification; protein glycosylation

Structure

belongs to the glycosyltransferase 29 family

Compartment

Golgi membrane

Expression

• highly expressed in fetal brain, kidney & heart & to a much lesser extent in adult heart & thymus

More general terms

• sialyltransferase
• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/602546
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8128
• UniProt: http://www.uniprot.org/uniprot/Q92186.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8128