sialyltransferase 8A; alpha-N-acetyl-neuraminide:alpha-2,8-sialyltransferase; ganglioside GD3/GT3 synthase (ST8SIAI, ST8SIA1)

Function

• role in the production of GD3 & GT3 from GM3
• protein modification; protein glycosylation

CMP-N-acetylneuraminate +
alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R
           <-->
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl- 2,3-beta-D-galactosyl-R

Structure

belongs to the glycosyltransferase 29 family

Compartment

Golgi membrane

Expression

• strongly expressed in melanoma cell lines, adult & fetal brain & to a lesser extent in adult & fetal lung

More general terms

• sialyltransferase
• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/601123
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6489
• UniProt: http://www.uniprot.org/uniprot/Q92185.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6489