sialyltransferase 3C; sialyltransferase 7D; NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase IV (SIAT3C, SIAT7D, ST6GALNAC4)

Function

• role in biosynthesis of ganglioside GD1A from GM1B
• transfers CMP-neuAc with an alpha-2,6-linkage to galNAc residue on neuAc-alpha-2,3-gal-beta-1,3-galNAc of glycoproteins & glycolipids
• prefers glycoproteins to glycolipids
• protein modification; protein glycosylation

CMP-N-acetylneuraminate +
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminyl-R
        <-->
CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl- (1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D- galactosaminyl-R

Structure

belongs to the glycosyltransferase 29 family

Compartment

Golgi membrane

Expression

ubiquitous

More general terms

• sialyltransferase
• membrane protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2709
• OMIM: https://mirror.omim.org/entry/606378
• UniProt: http://www.uniprot.org/uniprot/Q9H4F1.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27090