sialyltransferase 1; beta-galactoside alpha-2,6-sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase; alpha 2,6-ST, B-cell antigen CD75 (SIAT1, ST6GAL1)

Function

• transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates
• protein modification; protein glycosylation
• the soluble form derives from the membrane form by proteolytic processing
• the HB-6, CDW75, & CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme

CMP-N-acetylneuraminate +
beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
              <-->
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-
1,4-N-acetyl-beta-D-glucosamine

Structure

belongs to the glycosyltransferase 29 family

Compartment

• Golgi, Golgi stack membrane
• secreted
• membrane-bound form in trans cisternae of Golgi
• secreted into the body fluid

More general terms

• sialyltransferase
• glycoprotein
• membrane protein

Additional terms

• CD75 antigen; lactosamine

Database

• UniProt: http://www.uniprot.org/uniprot/P15907.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6480
• OMIM: https://mirror.omim.org/entry/109675
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6480