Vezatin (VEZT)

Function

• role in the establishment of adherens junctions & their maintenance in adult life
• interacts with myosin VIIa & the cadherin-catenins complex

Structure

belongs to the vezatin family

Compartment

• cell membrane; multi-pass membrane protein
• cell junction, adherens junction
• nucleus
• cytoplasmic vesicle, secretory vesicle
• acrosome (putative)

Alternative splicing

named isoforms=6

Pathology

• in the case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site

More general terms

• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55591
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55591
• UniProt: http://www.uniprot.org/uniprot/Q9HBM0.html