semaphorin-4A; semaphorin-B; sema B (SEMA4A, SEMAB, SEMB, UNQ783/PRO1317)

Function

• inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons

Structure

• belongs to the semaphorin family
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 PSI domain
• contains 1 sema domain

Compartment

• membrane; single-pass type 1 membrane protein (putative)

Pathology

• defects in SEMA4A are the cause of
  • retinitis pigmentosa type 35
  • cone-rod dystrophy type 10

More general terms

• membrane protein
• glycoprotein
• semaphorin or semaphorin/collapsin family protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64218
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64218
• OMIM: https://mirror.omim.org/entry/607292
• OMIM: https://mirror.omim.org/entry/610282
• OMIM: https://mirror.omim.org/entry/610283
• UniProt: http://www.uniprot.org/uniprot/Q9H3S1.html