Rod outer segment membrane protein 1; ROSP1; tetraspanin-23; Tspan-23 (ROM1, TSPAN23)

Function

• may function as an adhesion molecule involved in stabilization & compaction of outer segment disks or in maintenance of the curvature of the rim
• essential for disk morphogenesis
• probably forms a complex with a PRPH2 homodimer; other proteins could associate with this complex in rods

Structure

• homodimer; disulfide-linked
• belongs to the PRPH2/ROM1 family

Compartment

membrane

Expression

• retina (photoreceptor)
• n rim region of rod outer segment disks

Pathology

• defects in ROM1 may cause retinitis pigmentosa when associated with defects in PRPH2

More general terms

• tetraspanin (transmembrane-4-superprotein)

Database

• UniProt: http://www.uniprot.org/uniprot/Q03395.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6094
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6094
• OMIM: https://mirror.omim.org/entry/180721
• OMIM: https://mirror.omim.org/entry/268000