cerebellin-1 (CBLN1)

Function

• neuromodulatory functions
• stimulates norepinephrine release via the adenylate cyclase PKA-dependent signaling pathway
• indirectly enhances adrenocortical secretion in vivo via a paracrine mechanism involving medullary catecholamine release
• forms complexes with CBLN3
• contains 1 C1q domain

Compartment

• secreted, membrane
• in the Purkinje cells postsynaptic structures

Expression

• low at birth, increases days 5-15, reaches peak values day 21-56

More general terms

• cerebellin
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P23435.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=869
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:869
• OMIM: https://mirror.omim.org/entry/600432