squalene synthetase (farnesyl-diphosphate farnesyltransferase, FDFT1, SQS)

Function

• steroid biosynthesis
• terpenoid biosynthesis

2 farnesyl diphosphate <--> diphosphate + presqualene diphosphate

presqualene diphosphate + NADH/NADPH
            <-->
squalene + diphosphate + NAD+/NADP+

Cofactor: Mg+2

Structure

• monomer (putative)
• belongs to the phytoene/squalene synthetase family

Compartment

• endoplasmic reticulum membrane

More general terms

• oxidoreductase
• prenyltransferase
• membrane protein

Additional terms

• cholesterol biosynthesis

Database

• UniProt: http://www.uniprot.org/uniprot/P37268.html
• OMIM: https://mirror.omim.org/entry/184420
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2222