17 beta-hydroxysteroid dehydrogenase-2 [microsomal] (estradiol 17 beta-dehydrogenase 2, 20 alpha-hydroxysteroid dehydrogenase, HSD17B2)

Function

• interconversion of testosterone & androstenedione
• interconversion of estradiol & estrone
• 20-alpha-hydroxysteroid dehydrogenase activity (uses NADH)

17-beta estradiol + NADP+ <--> estrone + NADPH

Kinetic parameters:

• KM=0.21 uM, Vmax=38 nmol/min/mg enzyme for estradiol
• KM=0.39 uM, Vmax=45 nmol/min/mg enzyme for testosterone
• KM=0.31 uM, Vmax=38 nmol/min/mg enzyme for dihydrotestosterone
• KM=0.78 uM, Vmax=6.6 nmol/min/mg enzyme for estrone
• KM=2.63 uM, Vmax=11.5 nmol/min/mg enzyme for androstenedione

Structure

• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

membrane

More general terms

• 17 beta-hydroxysteroid dehydrogenase
• 20-hydroxysteroid dehydrogenase or cortisone reductase
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/P37059.html
• OMIM: https://mirror.omim.org/entry/109685