proprotein convertase PC7 (proprotein convertase subtilisin/kexin type 7, subtilisin/kexin-like protease PC7, prohormone convertase PC7, PC8, hPC8, lymphoma proprotein convertase)

Function

• ubiquitous endoprotease activity within constitutive secretory pathways (putative)
• capable of cleavage at the RXXX[KR]R consensus motif
• inhibited by Zn+2 & copper (putative)
• release of mature proteins from their proproteins by cleavage of Arg-Xaa-Xaa-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid & Yaa is Arg or Lys

Cofactor: Ca+2 (putative)

Structure

• Cys in the cytoplasmic tail are probably palmitoylated
• N-glycosylated
• belongs to the peptidase S8 family
• contains 1 homo B/P domain

Compartment

• Golgi, trans-Golgi network membrane
• seems to be localized intracellularly to the trans Golgi network (putative)

Expression

• expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon & peripheral blood leukocytes

More general terms

• subtilase
• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/604872
• UniProt: http://www.uniprot.org/uniprot/Q16549.html