phospholipase D3 (PLD 3, choline phosphatase 3, phosphatidylcholine-hydrolyzing phospholipase D3, HindIII K4L homolog, Hu-K4, PLD3)
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Function
-..........-
phosphatidylcholine + H2O <--> choline + phosphatidate
Structure
- glycosylated
- belongs to the phospholipase D family
- contains 2 PLD phosphodiesterase domains
Compartment
endoplasmic reticulum membrane
Expression
- widely expressed
- expressed at higher level in brain
- expressed at low level in corpus callosum, suggesting that it is highly expressed in neurons
Pathology
- rare polymorphism in PLD3 increases risk for late-onset Alzheimer's disease[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q8IV08.html
- ↑ 2.0 2.1 Cruchaga C et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature 2013 Dec 11 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24336208