phospholipase D3 (PLD 3, choline phosphatase 3, phosphatidylcholine-hydrolyzing phospholipase D3, HindIII K4L homolog, Hu-K4, PLD3)

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Function

-..........-

phosphatidylcholine + H2O <--> choline + phosphatidate

Structure

Compartment

endoplasmic reticulum membrane

Expression

  • widely expressed
  • expressed at higher level in brain
  • expressed at low level in corpus callosum, suggesting that it is highly expressed in neurons

Pathology

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/Q8IV08.html
  2. 2.0 2.1 Cruchaga C et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature 2013 Dec 11 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24336208

Database