glucose-6-phosphatase 2 (G6Pase 2, G-6-Pase 2, islet-specific glucose-6-phosphatase catalytic subunit-related protein, G6PC2, IGRP)

Function

• may hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum
• may be responsible for glucose production through glycogenolysis & gluconeogenesis (putative)
• carbohydrate biosynthesis; gluconeogenesis

D-glucose 6-phosphate + H2O <--> D-glucose + phosphate

Kinetic parameters:

• KM=0.45 mM for glucose-6-phosphate (at pH 6.5)

Structure

• N-glycosylated
• non-glycosylated form is more unstable & is degraded through the proteasome
• belongs to the glucose-6-phosphatase family

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• specifically expressed in pancreas
• detected to a lower extent in testis
• expressed by most islet cells in the pancreas (at protein level)

More general terms

• glycoprotein
• glucosidase
• transmembrane 9 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5781
• OMIM: https://mirror.omim.org/entry/608058
• UniProt: http://www.uniprot.org/uniprot/Q9NQR9.html