prominin-2 (PROM-2, prominin-like protein 2, hPROML2, PROM2, PROML2, UNQ2521/PRO6014)

Function

• binds cholesterol (putative)

Structure

• glycosylated (putative)
• belongs to the prominin family

Compartment

• apical cell membrane
• basolateral cell membrane (putative)
• cell projection, microvillus membrane
• cell projection, cilium
• colocalizes with PROM1
• associates with membrane (cholesterol-dependent)
• localizes to the apical & basolateral membranes of epithelial cells (putative)

Alternative splicing

named isoforms=3

Expression

• present in saliva within small membrane particles (at protein level)
• expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland, adrenal gland, placenta, stomach, spinal cord & liver.
• in submucosal tumor, expressed in spindle-shaped or stellate stromal cells

Pathology

• expressed in prostate cancer cell lines

More general terms

• glycoprotein
• transmembrane 5 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1506
• UniProt: http://www.uniprot.org/uniprot/Q8N271.html