prolyl 4-hydroxylase subunit alpha-3 (4-PH alpha-3, procollagen-proline, 2-oxoglutarate-4-dioxygenase subunit alpha-3, P4HA3)

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Function

  • catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-gly- sequences in collagens & other proteins
procollagen L-proline + 2-oxoglutarate + O2
               <-->
procollagen trans-4-hydroxy-L-proline + succinate + CO2

Cofactor: iron, ascorbate

Structure

Compartment

endoplasmic reticulum lumen (probable)

Alternative splicing

named isoforms=2

Expression

Pathology

More general terms

References

Database