cysteine-rich motor neuron 2 protein (CRIM-2, cysteine-rich BMP regulator 2, Kielin/chordin-like protein 1, CRIM2, KCP1, KCP)

Function

• enhances bone morphogenetic proteins (BMPs) signaling in a paracrine manner
• in contrast, it inhibits both activin-A & TGF-beta-1-mediated signaling pathway (putative)
• interacts with BMP7 &, by doing so, enhances binding to the type 1 receptors that contain cytoplasmic serine/threonine protein kinase domains
• able to interact with activin-A & TGF-beta 1 (putative)

Structure

contains 11 VWFC domains

Compartment

secreted (putative)

More general terms

• glycoprotein
• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6ZWJ8.html