plasma glutamate carboxypeptidase (PGCP, CPQ)

Function

• carboxypeptidase
• may play an important role in the hydrolysis of circulating peptides

Structure

belongs to the peptidase M28 family

Compartment

secreted

Expression

• mainly detected in blood plasma
• abundant in placenta & kidney
• present at low level in muscles, liver & skin fibroblasts
• not detected in brain or white blood cells (at protein level)

Pathology

• up-regulated in the majority of hepatitis C virus-associated hepatocellular carcinoma

More general terms

• carboxypeptidase
• secreted protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y646.html