K+ channel subfamily K member 18 (TWIK-related individual K+ channel, TWIK-related spinal cord K+ channel, KCNK18, TRESK, TRIK)

Function

• outward rectifying K+ channel
• produces rapidly activating outward rectifier K(+) currents
• may function as background K+ channel that sets the resting membrane potential
• inhibited by arachidonic acid & other naturally occurring unsaturated free fatty acids
• channel activity is enhanced by volatile anesthetics, including as isoflurane

Structure

• belongs to the two pore domain K+ channel (TC 1.A.1.8) family

Compartment

membrane

Expression

detected at low levels in spinal cord

More general terms

• K+ channel subfamily K
• phosphoprotein
• glycoprotein
• transmembrane 6 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z418.html