K+ voltage-gated channel subfamily A member 7 (voltage-gated K+ channel subunit Kv1.7, KCNA7)

Function

• mediates the voltage-dependent K+ permeability of excitable membranes
• K+-selective channel through which K+ ions may pass in accordance with their electrochemical gradient (putative)
• heterotetramer of K+ channel proteins

Structure

• N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments (putative)
• segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position (putative)
• belongs to the K+ channel family, A (Shaker) subfamily

Compartment

membrane

Expression

highly expressed in skeletal muscle, heart & kidney

More general terms

• K+ channel subfamily A (Shaker)
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/176268
• UniProt: http://www.uniprot.org/uniprot/Q96RP8.html