2-acylglycerol O-acyltransferase 3 (monoacylglycerol O-acyltransferase 3, acyl CoA:monoacylglycerol acyltransferase 3, MGAT3, diacylglycerol acyltransferase 2-like protein 7, diacylglycerol O-acyltransferase candidate 7, hDC7, MOGAT3, DC7, DGAT2L7, UNQ9383/PRO34208)
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Function
- catalyzes the formation of diacylglycerol from 2-monoacylglycerol & fatty acyl-CoA
- catalyzes terminal step in triacylglycerol synthesis by using diacylglycerol & fatty acyl CoA as substrates.
- preference toward palmitoyl-CoA & oleoyl-CoA
- role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes
- triacylglycerol synthesis
Acyl-CoA + 2-acylglycerol <--> CoA + diacylglycerol
Acyl-CoA + 1,2-diacylglycerol <--> CoA + triacylglycerol
- Vmax=9.3 nmol/min/mg enzyme with diacylglycerol as substrate
- Vmax=22.8 nmol/min/mg enzyme with 2-monoacylglycerol as substrate
Structure
belongs to the diacylglycerol acyltransferase family
Compartment
- endoplasmic reticulum membrane
Alternative splicing
named isoforms=3
Expression
- selectively expressed in the digestive system
- expressed in the ileum > jejunum, duodenum, colon, cecum & rectum
- not expressed in stomach, esophagus or trachea
- expressed at very low level in liver