alkaline phytoceramidase; aPHC; alkaline ceramidase; alkaline dihydroceramidase SB89 (PHCA, APHC, ACER3)

Function

• hydrolyzes only phytoceramide into phytosphingosine & free fatty acid
• does not have reverse activity
• activated by Ca+2 & inhibited by Zn+2

Structure

belongs to the alkaline ceramidase family

Compartment

• endoplasmic reticulum membrane
• Golgi membrane

Expression

• ubiquitously expressed
• highest expression in placenta

More general terms

• transmembrane 7 protein
• ceramidase
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NUN7.html