perforant pathway
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Introduction
One of 2 neural pathways* projecting from the entorhinal cortex to the hippocampus. It is the 1st fiber pathway of the trisynaptic circuit through the hippocampal formation. Fibers originate in layers 2 & 3 of the lateral entorhinal cortex & synapse on granule cell dendrites in the outer 2/3 of the molecular layer of the dentate gyrus & on apical dentrites of pyramidal cells in CA1-3 of the hippocampus.
Long-term potentiation (LTP) is observed in association with the perforant pathway.
* the other is the alvear path
So named because if perforates the subiculum.
More general terms
Additional terms
- dentate gyrus
- entorhinal cortex (Brodmann's area 28)
- long term potentiation (LTP)
- trisynaptic circuit
References
- ↑ Principles of Neural Science, 4th ed., Kandel, Schwartz & Jessell (eds), McGraw-Hill/Elsevier, NY, 2000, pg 1259
- ↑ The Human Nervous System, George Paxinos, Academic Press, San Diego CA 1990
- ↑ Mizutani T, Kashara M. Degeneration of the intrahippocampal routes of the perforant and alvear pathways in senile dementia of Alzheimer type. Neurosci Lett. 1995 Jan 23;184(2):141-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7724049