extracellular sulfatase Sulf-2 (HSulf-2, SULF2, KIAA1247, UNQ559/PRO1120)

Function

• sulfatase, has arylsulfatase activity
• highly specific endoglucosamine-6-sulfatase activity
• can remove sulfate from C-6 position of glucosamine within specific subregions of intact heparin.
• binds 1 Ca+2 per subunit

Kinetic parameters:

• Optimum pH is 7.0-8.0

Structure

belongs to the sulfatase family

Compartment

endoplasmic reticulum, Golgi, cell surface

Alternative splicing

named isoforms=2

Expression

• expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney, placenta

More general terms

• sulfatase
• Ca+2 binding protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IWU5.html