transmembrane serine protease 9; polyserase-1; polyserine protease 1 [Contains: serase-1; serase-2; serase-3] (TMPRSS9)
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Function
- precusor for serase-1, serase-2 & serase-3
- proteolytically cleaved to generate 3 independent serine protease chains
Structure
- serine protease 1 & 2 domains are catalytically active
- serine protease 3 domain lacks the essential Ser catalytic triad at position 1009, thus is predicted to be inactive
- proteolytically cleaved to generate 3 independent serine protease chain
- cleaved chains may remain attached to the membrane via disufide bonds
- unclear whether cleavage always takes place
- belongs to the peptidase S1 family
- contains 1 LDL-receptor class A domain
- contains 3 peptidase S1 domains
Compartment
Alternative splicing
named isoforms=2
Expression
- expressed in fetal human tissues, including kidney, liver, lung, brain
- weakly expressed in adult tissues, including skeletal muscle, liver, placenta, heart
Pathology
- expressed in a variety of tumor cell lines