N-acylethanolamine-hydrolyzing acid amidase; N-acylsphingosine amidohydrolase-like; ASAH-like protein; acid ceramidase-like protein (ASAHL, NAAA, PLT)

Function

• degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N- palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine
• weak hydrolytic activity against the ceramides N-lauroylsphingosine & N-palmitoylsphingosine
• stimulated by DTT & Nonidet P-40
• tunicamycin diminishes activity against N-palmitoylethanolamine

Kinetic parameters:

• KM=97 uM for N-palmitoylethanolamine
• Optimum pH is 4.5 with N-palmitoylethanolamine as substrate

Structure

N-glycosylated

Compartment

lysosome

Alternative splicing

named isoforms=3

Expression

expressed in liver & kidney > pancreas, other tissues

More general terms

• amidohydrolase
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607469
• UniProt: http://www.uniprot.org/uniprot/Q02083.html