N-acetylmuramoyl-L-alanine amidase; peptidoglycan recognition protein long; PGRP-L; peptidoglycan recognition protein 2 (PGLYRP2, PGLYRPL, PGRPL, UNQ3103/PRO10102)

Function

• scavenger
• digests biologically active peptidoglycan into biologically inactive fragments
• no direct bacteriolytic activity
• hydrolyzes link between N-acetylmuramoyl residues & L-amino acid residues in certain cell-wall glycopeptides

Cofactor: Zn+2

Structure

• belongs to the N-acetylmuramoyl-L-alanine amidase 2 family

Compartment

secreted, membrane

Alternative splicing

• named isoforms=2;
• may be due to an intron retention

Expression

• expressed in adult liver & fetal liver & secreted into plasma
• expressed to a much lesser extent in transverse colon, lymph nodes, heart, thymus, pancreas, descending colon, stomach, testis
• isoform 2 is not detected in the liver or plasma

More general terms

• metalloprotein
• hydrolase
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=114770
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:114770
• OMIM: https://mirror.omim.org/entry/608199
• UniProt: http://www.uniprot.org/uniprot/Q96PD5.html