N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L; ileal dipeptidylpeptidase; 100 kD ileum brush border membrane protein; I100 (NAALADL1, NAALADASEL, NAALADL)
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Function
- NAALADase-like activity unknown
- no NAAG hydrolyzing activity
- dipeptidyl-peptidase IV type activity
- cleaves Gly-Pro-AMC in vitro
- release of an unsubstituted, C-terminal glutamyl residue, generally from Ac-Asp-Glu or folylpoly-gamma glutamates
- binds 2 Zn+2 per subunit
Structure
belongs to the peptidase M28 family, M28B subfamily
Compartment
- cell membrane, apical cell membrane
- ileal brush border membrane
Alternative splicing
named isoforms=8
Expression
- expressed in the distal small intestine
- also expressed in the spleen & testis
- weak expression in the brain, mainly brain stem, amygdala, thalamus, ventral striatum