cholesterol 25-hydroxylase; cholesterol 25-monooxygenase; h25OH (CH25H)

Function

• catalyzes the formation of 25-hydroxycholesterol from cholesterol, inhibiting cholesterol biosynthesis
• regulates lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing
• Leydig cell differentiation in testis

Structure

• N-glycosylated
• belongs to the sterol desaturase family

Compartment

endoplasmic reticulum

Pathology

• Not associated with susceptibility to Alzheimer disease

More general terms

• hydroxylase; monooxygenase
• transmembrane 3 protein
• glycoprotein

Additional terms

• 25-OH-cholesterol

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9023
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9023
• OMIM: https://mirror.omim.org/entry/604551
• UniProt: http://www.uniprot.org/uniprot/O95992.html