Kremen protein 2 (Kringle-containing protein marking the eye & the nose, Kringle domain-containing transmembrane protein 2, Dickkopf receptor 2, KREMEN2, KRM2)

Function

• receptor for Dickkopf protein
• cooperates with Dickkopf to block Wnt/beta-catenin signaling
• forms a ternary complex with Dkk1 & LRP6 & induces rapid endocytosis & removal of Wnt receptor LRP6 from the plasma membrane

Structure

• contains 1 CUB domain
• contains 1 kringle domain
• contains 1 WSC domain

Compartment

membrane

Alternative splicing

named isoforms=4

More general terms

• cell surface receptor
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NCW0.html