Na+/K+/Ca+2 exchanger 6, mitochondrial; Na+/K+/Ca+2-exchange protein 6; Na+/Ca+2 exchanger protein, mitochondrial; solute carrier family 24 member 6; solute carrier family 8 member B1 (SLC8B1, NCKX6, NCLX, SLC24A6)

Function

• mitochondrial Na+/Ca+2 antiporter
• mediates Ca+-dependent Ca+2 efflux from mitochondria
• regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion:
  • acts by mediating efflux of Ca+2 from mitochondrion, thus affecting cytoplasmic Ca+2 responses
• transports Ca+2 in exchange for either Li+ or Na+
• in contrast to other members of the family, its function is independent of K+ Inhibitor: Zn+2

Structure

• belongs to the sodium/potassium/calcium exchanger family, SLC24A subfamily.

Compartment

• mitochondrial inner membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• present in pancreatic beta-cells (at protein level)

More general terms

• solute carrier family 24 (SLC24, SLC24A)
• solute carrier family 8 (SLC8, SLC8A, Na+/Ca+2 exchanger)
• glycoprotein
• transmembrane 13 protein
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6J4K2.html