DnaJ homolog subfamily C member 10 (ER-resident protein ERdj5, macrothioredoxin, MTHr, DNAJC10, ERDJ5, UNQ495/PRO1012)

Function

• endoplasmic reticulum co-chaperone may play a role in protein folding & translocation across the endoplasmic reticulum membrane
• may act as a co-chaperone for HSPA5
• interacts with HSPA5 via its J domain

Structure

• contains 1 J domain
• contains 4 thioredoxin domains

Compartment

secreted, endoplasmic reticulum lumen

Alternative splicing

named isoforms=2

Expression

induced during ER stress

More general terms

• DNAJ homolog subfamily C
• secreted protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607987
• UniProt: http://www.uniprot.org/uniprot/Q8IXB1.html