pulmonary surfactant-associated protein A2 (SP-A2, SP-A, PSP-A, PSPA, alveolar proteinosis protein, 35 kD pulmonary surfactant-associated protein, SFTPA2, PSAP, SFTP1, SFTPA)

Function

• binds to surfactant phospholipids in presence of Ca+2 & contributes to lower the surface tension at the air-liquid interface in the alveoli of the lung
• essential for normal respiration

Structure

• oligomeric complex of 6 set of homotrimers
• contains 1 C-type lectin domain.
• contains 1 collagen-like domain

Compartment

secreted

More general terms

• secreted protein
• glycoprotein

Additional terms

• pulmonary surfactant-associated protein A1; PSP-A; PSPA; SP-A; SP-A1; 35 kD pulmonary surfactant-associated protein; Alveolar proteinosis protein; collectin-4 (SFTPA1, COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B)

Database

• OMIM: https://mirror.omim.org/entry/178642
• UniProt: http://www.uniprot.org/uniprot/Q8IWL1.html