myocilin (trabecular meshwork-induced glucocorticoid response protein, MYOC, GLC1A, TIGR)

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Function

  • role in obstruction of fluid outflow in the trabecular meshwork
  • interacts with OLFM3

Structure

Compartment

Expression

Pathology

  • role in obstruction of fluid outflow in the trabecular meshwork
  • glaucomatous eyes,found in more regions of meshwork & is more intensively expressed than in normal eyes, regardless of the type or clinical severity of glaucoma
  • defects in MYOC are a cause of adult-onset primary open angle glaucoma
  • defects in MYOC are a cause of juvenile-onset primary open angle glaucoma

More general terms

References

Database