myocilin (trabecular meshwork-induced glucocorticoid response protein, MYOC, GLC1A, TIGR)
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Function
- role in obstruction of fluid outflow in the trabecular meshwork
- interacts with OLFM3
Structure
- homodimer
- contains 1 olfactomedin-like domain
- glycosylated
Compartment
- ciliary rootlet & basal body of connecting cilium of photoreceptor cells
- rough endoplasmic reticulum
- secreted Different isoforms may arise by post-translational modification
Expression
- expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart & other tissues
- expressed predominantly in the retina
- in normal eyes, found in the inner uveal meshwork region & the anterior portion of the meshwork
Pathology
- role in obstruction of fluid outflow in the trabecular meshwork
- glaucomatous eyes,found in more regions of meshwork & is more intensively expressed than in normal eyes, regardless of the type or clinical severity of glaucoma
- defects in MYOC are a cause of adult-onset primary open angle glaucoma
- defects in MYOC are a cause of juvenile-onset primary open angle glaucoma