solute carrier family 13 member 5 (Na+/citrate cotransporter, NaCT, Na+-coupled citrate transporter, Na+-dependent citrate transporter, SLC13A5, NACT)

Function

• high-affinity Na+/citrate cotransporter
• mediates citrate entry into cells
• transport process is electrogenic
  • trivalent form of citrate rather than divalent form is recognized as a substrate
• facilitates utilization of circulating citrate for generation of metabolic energy for synthesis of fatty acids & cholesterol

Structure

• belongs to the SLC13A transporter (TC 2.A.47) family, NADC subfamily

Compartment

membrane

Expression

• expressed in liver > brain, testis

More general terms

• transmembrane 12 protein
• glycoprotein
• solute carrier family 13 (SLC13, SLC13A)

Database

• OMIM: https://mirror.omim.org/entry/608305
• UniProt: http://www.uniprot.org/uniprot/Q86YT5.html