lumican (keratan sulfate proteoglycan lumican, KSPG lumican, LUM, LDC)

Function

• binds to laminin

Structure

• contains 12 LRR (leucine-rich repeats)

Compartment

secreted, extracellular matrix

Expression

• expressed in cornea & other tissues
• present in the extracellular matrix of human articular cartilage at all ages
• abundance is far greater in the adult
• in adult cartilage, lumican exists largely as glycoprotein lacking keratan sulfate; the juvenile form is a proteoglycan

More general terms

• secreted protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/600616
• UniProt: http://www.uniprot.org/uniprot/P51884.html