solute carrier family 14 member 2; urea transporter 2; urea transporter, kidney; vasopressin-sensitive urea transporter (SLC14A2, HUT2, UT2)

Function

• specialized low-affinity vasopressin-regulated urea transporter
• mediates rapid transepithelial urea transport across the inner medullary collecting duct & plays a major role in the urinary concentrating mechanism
• isoform 1 interacts with SNAPIN which may be important for recruitment to the plasma membrane

Structure

• belongs to the urea transporter family

Compartment

• apical cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• isoform 1 & isoform 2 are expressed in the inner renal medulla
• isoform 1 is induced by low protein in the diet
• isoform 2 is induced by dehydration

More general terms

• transmembrane 10 protein
• glycoprotein
• solute carrier family 14 (SLC14, SLC14A)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8170
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8170
• OMIM: https://mirror.omim.org/entry/601611
• UniProt: http://www.uniprot.org/uniprot/Q15849.html