K+/Na+ hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3 KIAA1535)

Function

• putative hyperpolarization-activated ion channel
• exhibits weak selectivity for K+ over Na+
• the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits

Structure

• the segment S4 is probably the voltage-sensor; it is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel HCN family
• contains 1 cyclic nucleotide-binding domain

Compartment

membrane

More general terms

• hyperpolarization-activated cyclic nucleotide gated K+ channel
• transmembrane 6 protein
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57657
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57657
• OMIM: https://mirror.omim.org/entry/609973
• UniProt: http://www.uniprot.org/uniprot/Q9P1Z3.html