dipeptidyl peptidase 2; dipeptidyl aminopeptidase II; dipeptidyl peptidase 7; dipeptidyl peptidase II; DPP II; quiescent cell proline dipeptidase (DPP7, DPP2, QPP)

Function

• role in degradation of some oligopeptides
• release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro
• substrates are oligopeptides, preferentially tripeptides
• pH dependence:
  • optimum pH is 5.5.
  • low activity at pH 7
  • inactive at pH 8

Structure

• N-glycosylated
• homodimer
• belongs to the peptidase S28 family

Compartment

• lysosome, cytoplasmic vesicle, secreted

Expression

• detected in seminal plasma (at protein level)

More general terms

• dipeptidyl peptidase (DPP)
• aminopeptidase
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29952
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29952
• OMIM: https://mirror.omim.org/entry/610537
• UniProt: http://www.uniprot.org/uniprot/Q9UHL4.html