neuropeptide FF receptor 2; G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; neuropeptide G-protein coupled receptor (NPFFR2, GPR74, NPFF2, NPGPR)

Function

• receptor for NPAF (A-18-F-amide) & NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides
• can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands.
• mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=4

Expression

• isoform 1
  • abundant in placenta
  • highly expressed in thymus, testis, & small intestine
  • expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver & pancreas
  • not expressed in skeletal muscle & leukocytes
• isoform 2
  • expression is highest in placenta (relatively low level compared to isoform 1)
  • very low level of expression in other tissues including adipose tissue & many brain regions
• isoform 3 is expressed in brain & hear > kidney, liver, lung & pancreas

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10886
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10886
• OMIM: https://mirror.omim.org/entry/607449
• UniProt: http://www.uniprot.org/uniprot/Q9Y5X5.html